Russell Crowe was Singer's first choice to play Wolverine. After Crowe turned the role down due to salary demands, a number of actors offered their services for the role before Singer cast Dougray Scott. Part of Scott's contract included a sequel, but Scott backed out due to scheduling conflicts with Mission: Impossible II in early October 1999. Hugh Jackman, who was an unknown actor at the time, was cast three weeks into filming. Keanu Reeves also expressed interest in the role.
Singer first suggested to Patrick Stewart that he play Xavier while X-Men executive producer Richard Donner was filming 1997's Conspiracy Theory. James Caviezel was originally cast as Cyclops, but backed out due to scheduling conflicts with Frequency. James Marsden was unfamiliar with his character, but soon became accustomed after reading various comic books. Marsden modeled his performance similar to a Boy Scout. Eric Mabius expressed interest for the role of Cyclops. Angela Bassett was approached to portray Storm in late 1997, as was Janet Jackson. Anna Paquin dropped out of the lead role in Tart in favor of X-Men. Terence Stamp was considered for Magneto before Singer cast Ian McKellen, who acted in his previous film, Apt Pupil. McKellen responded to the gay allegory of the film, "the allegory of the mutants as outsiders, disenfranchised and alone and coming to all of that at puberty when their difference manifests," Singer explained. "Ian is activist and he reality responded to the potential of that allegory." Thomas Jane turned down a role.
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